Epub 2015 Jul 30. A study across Europe found that PMLE affects as much as 18 percent of the population there. Scientists use genetic rewiring to increase lifespan of cells, Beyond amyloid and tau: New targets in developing dementia treatments, Napping longer than 30 minutes linked to higher risk of obesity and high blood pressure, Activity 'snacks' could lower blood sugar, complication risk in type 1 diabetes, What does erythema multiforme look like and how to treat it, Seborrheic dermatitis affecting the chest: What to know, eczematous, which causes dry patches and plaques, papulovesicular, which causes small blisters, erythema multiforme-like, which causes a rash of concentric circles, swelling caused by excess fluid in the upper part of the dermis, which is the middle layer of skin, the presence of cells from the immune system, including lymphocytes, dendritic cells, and T-cells, the formation of small blisters, or vesicles, lycopene, which is an antioxidant present in red fruits and vegetables, staying out of the sun when it is most intense, between, applying a mineral sunscreen with an SPF of 50 or above 1530 minutes before going outside, reapplying sunscreen every 2 hours and after getting the skin wet. National Library of Medicine [10], Fever, fatigue and headaches have been previously associated with the eruption, but are rare. doi:10.1016/j.det.2014.03.012. There is no cure for PLE, but the condition often gets better on its own in a few days. The eruption appears first on limited areas, but becomes more extensive during subsequent summers. If you have any concerns with your skin or its treatment, see a dermatologist for advice. Photohardening of polymorphic light eruption patients decreases baseline epidermal Langerhans cell density while increasing mast cell numbers in the papillary dermis. Treatment for burn blisters: Debride or leave intact? Some people are able to build a tolerance to UV light by gradually spending time outdoors or using phototherapy. Eruption refers to the sudden onset of the rash, usually within 30 minutes of UV light exposure. It most often (about 75% of cases) begins in females aged 20 to 40 years but may start in childhood or later in life. It has been noted that PMLE appears to be less frequent and severe in women after menopause. A PLE rash can look similar to other skin rashes, so it is important to get a diagnosis from a doctor. There may also be a link with estrogen, according to the 2022 review. PMLE is about four times more common in women than in men. PLE can look similar to other rashes, such as the rash that occurs in people with lupus erythematosus. Polymorphic light eruption (PMLE) is a form of photosensitivity, which usually occurs in younger females. Figure 1 The clinical manifestations befall within a few hours to days from light exposure, last a few days, and subside in about a week without sequelae. 2018 Jun; [PubMed PMID: 29430717], Choi D,Kannan S,Lim HW, Evaluation of patients with photodermatoses. Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. It is rare for people who get sunlight exposure year-round to have PLE. Polymorphous light eruption (PMLE) is a common skin rash that develops after exposure to ultraviolet (UV) light. If youre going someplace sunny on vacation, your healthcare provider may prescribe an oral corticosteroid like prednisone to reduce your chances of getting a rash. Is this condition temporary or long lasting? Current theories involve two steps that lead to a polymorphous light eruption. Polymorphic light eruption, Author(s): Dr Prudence Gramp, Dermatology Department, Gold Coast University Hospital, Australia. [4], PLE is more common in young adults and has a female preponderance[5] with a ratio of 2:1 female-to-male. This exposes the skin to small doses of UVA or UVB light that helps your skin be less sensitive to light. See additional information. Would you like email updates of new search results? In short, jock itch can spread between, Keloids can appear on your ear in response to any type of wound, including a piercing. doi:10.1016/j.jaad.2009.01.041. //]]>. What side effects can I expect from treatment? This could involve: When outside, try to wear lightweight clothes that cover the skin, such as loose long-sleeved tops or dresses. Have you recently used a tanning bed or lamp? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. There are often lymphocytes in the epidermis (exocytosis, figure 3). Winter occurrences likely due to solariums (tanning facilities) or a holiday to a sunnier climate. [15], Oxidative stress and the modification of the redox status of the skin has been implicated in the expression of PLE. [3] The bumps may become small blisters or plaques and may appear bloody,[3]often healing with minimal scarring. [2] If resistant, the administration of hydroxychloroquine in early spring is sometimes considered. [6], Half of patients have a family history of PLE,[6] demonstrating a clear genetic influence. Duration: can last from days to weeks and resolves faster if further sun exposure is avoided. Polymorphic light eruption (PLE) is the most common photodermatosis, with a prevalence of 10-20% in the North American and European population ( 1,2 ). Because PMLE is more prevalent in women than men, it is hypothesized that there is a hormonal component to its pathogenesis. As the name suggests, clinical features can vary poly meaning many, morphic meaning forms. However, positive antinuclear antibody and extractable nuclear antigen (anti-Ro/La) in low titer may be detected, even in the absence of other criteria to suggest a diagnosis of lupus erythematosus. However, the rash of lupus is inclined to be more persistent. Advertising on our site helps support our mission. It usually takes the form of an irritated rash that comes hours to days after exposure to direct sunlight. Koulu LM, Laihia JK, Peltoniemi HH, Jansn CT. J Invest Dermatol. None are generally needed. The rash may consist of small red bumps, larger red patches or even blisters. [2], The rash may persist for many days to a couple of weeks,[5] resolving spontaneously without scarring as long as further sunlight exposure is avoided. 13th ed. [6]. Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. MeSH In this article, learn about the symptoms, causes, and treatment of erythema. Your healthcare provider can suggest ways to protect your skin from UV light and prevent PMLE. In the northern hemisphere, people who are prone to PLE often experience this condition in spring, when light levels begin to increase and people start wearing clothes for warmer weather. To reduce the effects of PMLE, the American Academy of Dermatology (AAD) recommends seeking shade and applying sunscreen. It is primarily caused by either UVA (7590%) or UVB light alone or UVA and UVB light concurrently, UVA can penetrate window glass and some sunscreens do not protect against it. PLE mainly affects females with the mean disease onset being in the second to third decade of life ( 3,4 ). DermNet provides Google Translate, a free machine translation service. Polymorphic light eruption. Its also called polymorphic light eruption and prurigo aestivalis. Influence of the season on vitamin D levels and regulatory T cells in patients with polymorphic light eruption. DermNet provides Google Translate, a free machine translation service. Vitamin D insufficiency, the role of estrogen in preventing UV-induced immune suppression, and dysregulated antimicrobial factors may be relevant. (2018). PLE commonly affects people for many years, but most peoples symptoms improve or disappear over time. However, positive antinuclear antibody and extractable nuclear antigen (anti-Ro/La) in low titre may be found, even in the absence of other criteria to suggest a diagnosis of lupus erythematosus. It may affect up to 15% of people worldwide. Advertising revenue supports our not-for-profit mission. It occurs 1-2 days after intense sun exposure. 2010;130(2):6268. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Accessibility Accurate diagnosis relies on the exclusion of other photosensitive conditions. [25][26], Danish physician Carl Rasch first described the eczema-like polymorphic light eruption in 1900, following his interest in the effect of sunlight on the skin. A PLE rash does not usually leave scars or marks. 1986;3(5):298302. https://www.uptodate.com/contents/search. Bookshelf Its diagnosis is based on history, morphology and phototests. Polymorphic light eruption is a skin reaction that appears after exposure to direct sunlight or other forms of UV light. What to wear to protect your skin from the sun. [1]. sharing sensitive information, make sure youre on a federal Despite the fact that polymorphous light eruption (PLE) is the most common photodermatosis, affecting 15% of healthy people in the UK, its pathogeny remains unclear. It occurs after solar or artificial UV-light exposure and affects only the sun-exposed areas with preference of the V-area of the chest, of arms and forearms, legs, upper part of the back, and rarely the face. The site is secure. An examination of the skin to detect the rash is made, however, up to 40% have false negative responses. [16], The preponderance in women with a decline in severity following menopause has been thought to be associated with oestrogen effects,[6] A natural fall in oestrogens may account for the tendency to remit after the menopause. The rash doesnt cause scars. https://www.aad.org/media/stats-sunscreen. Author: A/Prof Patrick Emanuel, Dermatopathologist, Auckland, New Zealand, 2013. UVA causes up to 9 in 10 cases of polymorphous light eruption. There is often impressive papillary dermal oedema (figures 1, 2, 3). (2019). Both ultraviolet and occasionally visible light cause PMLE. Phototesting can be considered but is not carried out in all patients with PMLE. Dark lips are often the result of hyperpigmentation. 2008 May;58(5 Suppl 2):S149-54. [6], Those experiencing sun exposure all year round seldom acquire PLE eruption. James WD, et al. This hormone may prevent UV radiation from suppressing the skins immune responses. Accessed Nov. 12, 2021. Sunscreens containing the broad-spectrum UVA absorber, Mexoryl SX, prevent the cutaneous detrimental effects of UV exposure: a review of clinical study results. In northern Europe, it may affect 2040% of women holidaying in the Mediterranean area, whereas in Australasian areas it is estimated to only affect between 15% of people. Polymorphous light eruption (PMLE) is a common acquired disease entity belonging to the idiopathic photodermatoses. Some people with PLE may find they react to even small exposures to sunlight, while others develop PLE only after a certain amount of time in the sun or as a result of repeated exposures. Polymorphous means it looks different in different people. Solar urticaria occurs during or shortly after exposure and resolves within an hour or soof covering up. Doctors think it is a type of delayed allergic reaction. Skin diseases due to physical and chemical causes", https://en.wikipedia.org/w/index.php?title=Polymorphous_light_eruption&oldid=1127125983, Skin conditions resulting from physical factors, Pages containing links to subscription-only content, Creative Commons Attribution-ShareAlike License 3.0, Shortly after sun exposure in people younger than age 30-years, This page was last edited on 13 December 2022, at 01:14. Figure 2 Low-dose narrowband UV-B and other forms of phototherapy undertaken in late winter or early skin can reduce the incidence and severity of polymorphous light eruption. Look for clothes labeled with an ultraviolet protection factor (UPF) of 40 to 50. When your skin is exposed to sunlight, a rash will form within a few hours or days. FOIA Polymorphous light eruption (PMLE) is an acquired disease and is the most common of the idiopathic photodermatoses. Presents in temperate climates and is more common where sun exposure is uncommon. How is polymorphous light eruption diagnosed? Oakley AM, et al. [5] In addition, it may occur in other parts of the body in some people treated for inflammatory skin diseases with phototherapy. Its not as common, but you might have additional symptoms, like: Polymorphic means many forms, and PMLE can look different for different people. [2] When a decision to undertake this is made, a small area of the frequently affected skin is exposed to varying doses of UVA and minimal erythema dose (MED) (amount of UV radiation that will produce minimal redness of skin within a few hours following exposure)[2][17] of broadband UVB for three consecutive days. Learning Point. 2018 [PubMed PMID: 30250845], Gruber-Wackernagel A,Hofer A,Legat F,Wolf P, Frequency of occurrence of polymorphic light eruption in patients treated with photohardening and patients treated with phototherapy for other diseases. Exposure to sunlight in spring or summer results in an irritable rash that resolves within a few days, providing further exposure is avoided. Reported to be more common at higher altitudes compared to sea level regions. For severe rashes, your provider may prescribe: This is a recurrent condition that may last for years. Its important to note that, while UVA exposure is the typical cause, the rash can be a result of UVA or UVB exposure. Experts dont know exactly what causes this rash. Researchers are not sure what causes PLE, but they believe it may occur due to a reaction by the immune system. Gradual hardening is one form of treating PMLE. arrow-right-small-blue 2014;22:24. Several hours to days later, an irritablerash appears on areas newly exposed to the light such as the dcolletage, forearms, backs of hands, lower legs and feet. All rights reserved. American Academy of Dermatology. It is not always possible to completely prevent PLE in people who are prone to it. Polycystic Ovary Syndrome (PCOS) Polycystic ovary syndrome, or PCOS, is a set of symptoms related to a hormonal imbalance that can affect women and girls of reproductive age. Some people benefit from phototherapy as a way to harden their skin. Onset: occurs within several hours to 12 days after exposure to sunlight and is usually intermittent. . Reactions to physical agents. It is one of the most common sun-related skin problems and is most common among women and among people from northern climates who are not regularly exposed to the sun. 5th ed. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation. What's the most likely cause of my symptoms? The condition is more frequent in females and begins often in young adults and in mid-adult life. Women and people assigned female at birth. When in situations that are likely to provoke the rash, cover up as much as possible with densely woven clothing. Broad-spectrum sunscreens provide better protection from solar ultraviolet-simulated radiation and natural sunlight-induced immunosuppression in human beings. 8600 Rockville Pike It is generally itchy and uncomfortable. Lesions may vary from patient to patient; however, spontaneous resolution (on cessation of sun exposure) is often a unifying trait. In most patients with a polymorphic light eruption, blood tests willreveal normal results. Accessed Nov. 12, 2021. Sometimes, these papules appear in a dense formation, making the rash look similar to eczema or prickly heat. PLE is a rash that develops in response to sunlight exposure. [1][2], UV-A is theusualpart of the electromagnetic spectrum that provokes polymorphous light eruption (75% to 90%). [2], Artificial UV light sources from tanning units and phototherapy treatment units can also trigger PLE. Disclaimer. National Library of Medicine PMLE skin rash; information", "Decreased neutrophil skin infiltration after UVB exposure in patients with polymorphous light eruption", "Microbial elements as the initial triggers in the pathogenesis of polymorphic light eruption? When? There is someevidence to support prophylactic short courses of oral steroids (for example, to prevent the eruption during a holiday break), hydroxychloroquine, and antioxidants such as Polypodium leucotomes extract, lycopene, beta-carotene, nicotinamide and astaxanthin. Polymorphous light eruption (PMLE) is a common skin reaction in people who are sensitive to sunlight (ultraviolet light). It is more common in patients who receive only intermittent sun exposure and typically consists of crops of papules, vesicles or plaques. The role of diet in treating PLE requires more research. If you can, avoid the sun when its at its strongest during the middle of the day. PLE symptoms typically appear around 2 hours after sun exposure and last for several days before improving on their own. Consider wearing a broad-brimmed hat, which provides more protection than does a cap or visor. Consider wearing clothing designed to provide sun protection. Dermatologic clinics. [CDATA[ Photodermatol Photoimmunol Photomed. [4], Typically, the first episode develops in the spring following the first exposure to intense sun. In the northern hemisphere, people who are. If you develop a rash shortly after exposure to sunlight or artificial UV light, ask a healthcare provider if you could have polymorphous light eruption (PMLE). [9] Some progression to autoimmune disease has been observed. UV-induced tolerance to a contact allergen is impaired in polymorphic light eruption. 2015;29(1):97101. Epub 2017 Jul 17. Accessed Dec. 9, 2021. Clipboard, Search History, and several other advanced features are temporarily unavailable. Ultraviolet light has two types: UVA and UVB. May 2022. [15], There may be a possible link with autoimmune thyroid disease. Polymorphic light eruption is also known as polymorphous light eruption and prurigo aestivalis. Symptoms of polymorphic light eruption An itchy or burning rash appears within hours, or up to 2 to 3 days after exposure to sunlight. Please enable it to take advantage of the complete set of features! Using high SPF, broad-spectrum sunscreen, and wearing protective clothing helps minimize UV light exposure. The morphology can include eruptions that are: The morphology is, however, always the same in one patient. In PMLE patients, UV radiation leads to an increased amount of CD4 and CD8 T lymphocytes, and an increased inflammatory response in the epidermis and dermis. Photosensitivity. However, once the diagnosis is made, the patient may be monitored by the primary care physician and nurse practitioner. The papular type is the most common. Symptoms of PMLE usually begin within a few hours to days after sunlight exposure, typically in the spring or early summer. [1] It generally appears 30 minutes to a few hours after sun exposure and may last between one and 14 days. To exclude other photosensitive conditions a skin biopsy may be considered. You can learn more about how we ensure our content is accurate and current by reading our. Exposure to sunlight in spring or summer results in an irritable rash that resolves within a few days, providing further exposure is avoided. A long-term follow-up study of 94 patients", "13. PMLE is a delayed hypersensitivity reaction in the skin to unknown endogenous cutaneous photo-induced antigens. Polymorphous light eruption is the most common skin disease resulting from UV light exposure. It mimics the increased exposure you would experience during a summer. However, this study was small. Hematoxylin-eosin staining shows subepidermal edema and a mixed, predominantly lymphoid perivascular infiltrate in the superficial and deep dermis. Doctors still aren't completely sure why, but for people with PMLE, ultraviolet light from the sun stimulates an immune response that includes inflammation, swelling, itchiness, and a variety of rashes, including tiny blisters and raised, plaque-like skin. The symptoms are usually self-limiting and go away after a few days. Other medications that might be used to treat PMLE include: If you have an unexplained rash, you should make an appointment with a primary care physician or dermatologist. About three-quarters of patients acquire PLE after UV-A exposure only, one-tenth after UV-B exposure only, and the rest after a combination of UV-A and UV-B exposure. Most UV light you are exposed to comes from the sun. An official website of the United States government. When the condition first appears, the most common symptoms include: The rash will then appear on parts of the body that have had sun exposure, such as the: Some people also experience additional symptoms around 4 hours after sun exposure, such as: These additional symptoms typically last for only 12 hours. People with the condition usually experience symptoms at the same time of year, often when the skin first becomes exposed to sunlight after being covered up during winter. Do you have any brochures or other printed material I can take with me? Epub 2014 Mar 27. It occurs most often on areas of skin that haven't seen the sun for a while - it is more common on the arms and the . Polymorphous light eruption (PLE) presents with itchy red small bumps on sun-exposed skin, particularly face, neck, forearms and legs. Prevention of Polymorphic Light Eruption Afforded by a Very High Broad-Spectrum Protection Sunscreen Containing Ectoin. A 2014 study suggests that nutrition may also play a role in how sensitive a persons skin is to sun exposure. Frontiers in medicine. Books about skin diseasesBooks about the skin If PLE symptoms are mild, people may be able to manage the condition at home. Lupus Lupus will also show a superficial and deep dermatitis but there is also often basement membrane thickening and dermal mucin. The following factors must be considered when determining pathogenesis and when implementing protective measures: UV radiation usually creates an immunosuppressive response in the skin, however, patients with PMLE may have a reduction in this normal response. FOIA Have you had a fever associated with the rash? [12], Reports of psychological distress have been made in more than 40% of peoples with PLE. Reapply it every two hours or more often if you're swimming or sweating. Causes. Theories must account for increased prevalence in women and for the hardening effect of on-going exposure to ultraviolet radiation. Merck Manual Professional Version. Oakley A. The problem takes many forms, though it often appears as a red, itchy rash on areas exposed to the sun, except for the face. It's less likely to be repeated as the summer . You can learn more about how we ensure our content is accurate and current by reading our. PLE is a skin rash that occurs in response to sunlight. The https:// ensures that you are connecting to the One common type is polymorphic light exposure (PMLE). It does not seem to be associated with systemic disease or drugs. PLE is a relatively common skin disorder that is not easy to diagnose or manage. The most common morphology is smooth-topped erythematous papules, which can coalesce into plaques. Bethesda, MD 20894, Web Policies Last medically reviewed on November 23, 2022, An atypical skin reaction to sun exposure causes a sun rash. Experts have suggested it may also be at least partly associated with: While the causes of PMLE are still under investigation, the rash is brought on by UV light. What treatments are available, and which do you recommend? This activity reviews the pathophysiology of polymorphic light eruption and highlights the role of the interprofessional team in its management. Itchy, non-scarring lesions of distinct morphology are typical on sun-exposed body parts. Is it possible this condition is related to a more serious illness? To diagnose PLE, a doctor will ask questions about a persons symptoms, such as when they appear and what the rash feels like. Recently appearing lesions may show neutrophils. This is a type of distinct, circular bump that occurs due to, Erythema multiforme causes a distinctive rash resembling a bull's-eye. There is a genetic susceptibility in 1546% of cases where a positive family history is reported. This won't totally protect you from a reaction, as ultraviolet A may penetrate through most sunscreens. There is a phenomenon called the skin hardening effect where chronic exposure to sunlight leads to skin changes including increased melanin and thickening of the stratum corneum. The photo antigen that triggers this response is currently unknown. Gruber-Wackernagel A, Byrne SN, Wolf P. Polymorphous light eruption: clinic aspects and pathogenesis. Photochemical [PubMed PMID: 22961505], Richards HL,Ling TC,Evangelou G,Brooke RC,Fortune DG,Rhodes LE, Evidence of high levels of anxiety and depression in polymorphic light eruption and their association with clinical and demographic variables. But the severity often improves with time. ncbi.nlm.nih.gov/pmc/articles/PMC7379702/, ncbi.nlm.nih.gov/pmc/articles/PMC8323194/, ncbi.nlm.nih.gov/pmc/articles/PMC6139322/, dermnetnz.org/topics/polymorphic-light-eruption, nhs.uk/conditions/polymorphic-light-eruption/, aad.org/public/everyday-care/sun-protection/shade-clothing-sunscreen/what-to-wear-protect-skin-from-sun, Every Sunscreen Question You Have, Answered, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI. [5], Photosensitivity is also found in some of the porphyrias. This can explain why it is uncommon to get PMLE in areas of the face or hands due to their chronic exposure to the sun compared to other areas of the body. 2017 Nov 1;35(6):751-757. doi: 10.1016/j.biotechadv.2017.07.006. 2008 Aug;24(4):164-74. doi: 10.1111/j.1600-0781.2008.00365.x. PMLE can appear on any part of your body exposed to UV light, although it rarely appears on your face. Polymorphic light eruption is the most common form of immunologically mediated photosensitivity dermatoses. Whether administration of estrogen in the form of oral contraceptives or postmenopausal replacement therapy might induce high ANA levels in a healthy individual cannot be ascertained from our data. Affected individuals may experience it every time they go outdoors, or only occasionally. [1], The prevalence of polymorphic light eruption varies worldwide. Insight into immunocytes infiltrations in polymorphous light eruption. In some cases, a doctor might expose a small part of your skin to UV light in order to confirm PMLE. Dermatologic clinics. window.__mirage2 = {petok:"qA58IQ768GeOLKFViL7kQqLnoC_jvex_EJRsbmd4PEw-1800-0"}; We do not endorse non-Cleveland Clinic products or services. Elmets CA. Elsevier; 2020. https://www.clinicalkey.com. Polymorphous light eruption (PMLE). Jock itch and related conditions can cause discomfort and itchy, irritated skin. doi:10.1111/exd.12427. Wear a hat with a brim and large sunglasses to protect the face and shoes that cover the feet. Levels and function of regulatory T cells in patients with polymorphic light eruption: relation to photohardening. The course is 2 to 3 treatments per week for 4 to 6 weeks each year. Review the presentation of polymorphic light eruption. Smooth red-topped small papules which merge into plaques, small fluid-filled blisters (papulovesicles)[2] and less commonly target-shaped lesions which look like erythema multiforme may be visible. Polymorphic light eruption: an immunopathological study of evolving lesions. Epub 2010 Jul 8. van de Pas CB, Kelly DA, Seed PT, Young AR, Hawk JL, Walker SL. Polymorphous light eruption (PMLE) is an allergic reaction to sunlight or other sources of ultraviolet (UV) light. https://www.fda.gov/drugs/understanding-over-counter-medicines/sunscreen-how-help-protect-your-skin-sun. Phototherapy It occurs after solar or artificial UV-light exposure and affects only the sun-exposed areas with preference of the V-area of the chest, of arms and forearms, legs, upper part of the back, and rarely the face. Have you recently used a cosmetic or fragrance in the area of the rash? Unable to load your collection due to an error, Unable to load your delegates due to an error. It is postulated that there is a delayed hypersensitivity reaction to an endogenous antigen expressed after exposure to sunlight or artificial sources of ultraviolet (UV) radiation. Rarely, systemic features such as fever, malaise, and headaches, have been associated with the eruption. Polymorphous light eruption (PMLE) is a common skin rash that develops in people who are sensitive to ultraviolet (UV) light. Polymorphic light eruption is also known as polymorphous light eruption and prurigo aestivalis. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Journal of the European Academy of Dermatology and Venereology : JEADV. The lesions are itching or burning, and vary morphologically from erythema to papules, vesico-papules and occasionally blisters, plaques, sometimes erythema multiforme-like, insect bite-like wheals and purpura. It lasts for up to 2 weeks, healing without scarring. Topics AZ The infiltrate is mainly lymphocytic but there may be intermixed eosinophils, neutrophils, and histiocytes (figure 4). Polymorphic light eruption (PMLE) is a seasonal, acquired, idiopathic photodermatosisoccurring in spring and early summer. Direct immunofluorescence testing is negative.

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